Cargando…

Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease. In previous studies, small activating RNA against CCAAT/enhancer-binding protein-α (C/EBPα-saRNA) demonstrated efficacy of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoon, Sorah, Huang, Kai-Wen, Andrikakou, Pinelopi, Vasconcelos, Daniel, Swiderski, Piotr, Reebye, Vikash, Sodergren, Mikael, Habib, Nagy, Rossi, John J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796740/ https://www.ncbi.nlm.nih.gov/pubmed/31546149 http://dx.doi.org/10.1016/j.omtn.2019.08.017

Ejemplares similares

Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma-specific RNA Aptamers Inhibits Tumor Growth In Vivo
por: Yoon, Sorah, et al.
Publicado: (2016)

Gene activation of CEBPA using saRNA: Preclinical studies of the first in human saRNA drug candidate for liver cancer
por: Reebye, Vikash, et al.
Publicado: (2018)

Therapeutic Potential of small Activating RNAs (saRNAs) in Human Cancers
por: Yoon, Sorah, et al.
Publicado: (2018)

The evaluation of novel oral vaccines based on self-amplifying RNA lipid nanparticles (saRNA LNPs), saRNA transfected Lactobacillus plantarum LNPs, and saRNA transfected Lactobacillus plantarum to neutralize SARS-CoV-2 variants alpha and delta
por: Keikha, Reza, et al.
Publicado: (2021)

Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses
por: Liu, Yalan, et al.
Publicado: (2023)

Poly(2-oxazoline)/saRNA Polyplexes for Targeted and Nonviral Gene Delivery
por: Hayes, Graham, et al.
Publicado: (2023)

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer
por: Voutila, Jon, et al.
Publicado: (2017)

saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription
por: Portnoy, Victoria, et al.
Publicado: (2016)

AB224. SaRNA guided inos upregulation improves erectile function of diabetic rats
por: Wang, T, et al.
Publicado: (2014)

Reactivation of HIC-1 gene by saRNA inhibits clonogenicity and invasiveness in breast cancer cells
por: ZHAO, FENG, et al.
Publicado: (2015)

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA
por: Blakney, Anna K., et al.
Publicado: (2019)

Histone lysine methyltransferase-related neurodevelopmental disorders: current knowledge and saRNA future therapies
por: Roth, Charlotte, et al.
Publicado: (2023)

Biophysical characterization of the structure of a SARS-CoV-2 self-amplifying RNA (saRNA) vaccine
por: Myatt, Daniel P, et al.
Publicado: (2023)

Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis
por: Wang, Chenghe, et al.
Publicado: (2016)

Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach
por: Ly, Han Han, et al.
Publicado: (2022)

p21(CIP/WAF1) saRNA inhibits proliferative vitreoretinopathy in a rabbit model
por: Zhang, Qi, et al.
Publicado: (2023)

Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth
por: Yoon, Sorah, et al.
Publicado: (2017)

Cannabinoids in the landscape of cancer
por: Mangal, Nagina, et al.
Publicado: (2021)

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer
por: Blakney, Anna K., et al.
Publicado: (2020)

Upregulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Patients with Cancer
por: Hashimoto, Ayumi, et al.
Publicado: (2021)

Mechanism of Notch1-saRNA-1480 reversing androgen sensitivity in human metastatic castration-resistant prostate cancer
por: Ma, Libin, et al.
Publicado: (2020)

A Mutation in Endogenous saRNA miR-23a Influences Granulosa Cells Response to Oxidative Stress
por: Wang, Siqi, et al.
Publicado: (2022)

An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma
por: Yoon, Sorah, et al.
Publicado: (2018)

OX40 agonist stimulation increases and sustains humoral and cell-mediated responses to SARS-CoV-2 protein and saRNA vaccines
por: Duhen, Rebekka, et al.
Publicado: (2022)

saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern
por: Komori, Mai, et al.
Publicado: (2023)

C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC
por: Hartl, Leonie, et al.
Publicado: (2023)

Anti-inflammatory Activity of MTL-CEBPA, a Small Activating RNA Drug, in LPS-Stimulated Monocytes and Humanized Mice
por: Zhou, Jiehua, et al.
Publicado: (2019)

Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies
por: Rice, Adrian, et al.
Publicado: (2022)

C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration
por: Hartl, Leonie, et al.
Publicado: (2022)

MTL-CEBPA Combined with Immunotherapy or RFA Enhances Immunological Anti-Tumor Response in Preclinical Models
por: Huang, Kai-Wen, et al.
Publicado: (2021)

Aptamers: Uptake mechanisms and intracellular applications()
por: Yoon, Sorah, et al.
Publicado: (2018)

Targeted Molecular Imaging Using Aptamers in Cancer
por: Yoon, Sorah, et al.
Publicado: (2018)

On the behaviour of lung tissue under tension and compression
por: Andrikakou, Pinelopi, et al.
Publicado: (2016)

PPFIA1-targeting miR-181a mimic and saRNA overcome imatinib resistance in BCR-ABL1-independent chronic myeloid leukemia by suppressing leukemia stem cell regeneration
por: Su, Rui, et al.
Publicado: (2023)

Sarna: una epidemia dentro de una pandemia
por: Casals, Miquel
Publicado: (2021)

Regulatory role of RNA modifications in the treatment of pancreatic ductal adenocarcinoma (PDAC)
por: Chen, Hao, et al.
Publicado: (2023)

Upregulated MicroRNA-483-3p is an Early Event in Pancreatic Ductal Adenocarcinoma (PDAC) and as a Powerful Liquid Biopsy Biomarker in PDAC
por: Shao, Huilin, et al.
Publicado: (2021)

A Short-activating RNA Oligonucleotide Targeting the Islet β-cell Transcriptional Factor MafA in CD34(+) Cells
por: Reebye, Vikash, et al.
Publicado: (2013)

Tratamiento con Doramectina o Amitráz contra sarna Demodécica en perros /
por: Suárez Flores, Aglaé
Publicado: (2010)

Serum miRNA Profiling for Early PDAC Diagnosis and Prognosis: A Retrospective Study
por: Aita, Ada, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pkkjdj77e7jlju4puj265fdska