ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

Autophagy is critical for maintaining cellular homeostasis during times of stress, and is thought to play important roles in both tumorigenesis and tumor cell survival. Formation of autophagosomes, which mediate delivery of cytoplasmic cargo to lysosomes, requires multiple autophagy-related (ATG) pr...

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Detalles Bibliográficos
Autores principales: Wible, Daric J., Chao, Hsueh-Ping, Tang, Dean G., Bratton, Shawn B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796855/
https://www.ncbi.nlm.nih.gov/pubmed/31636955
http://dx.doi.org/10.1038/s41421-019-0110-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796855/
https://www.ncbi.nlm.nih.gov/pubmed/31636955
http://dx.doi.org/10.1038/s41421-019-0110-1

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