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Molecular basis for hierarchical histone de-β-hydroxybutyrylation by SIRT3

Chemical modifications on histones constitute a key mechanism for gene regulation in chromatin context. Recently, histone lysine β-hydroxybutyrylation (Kbhb) was identified as a new form of histone acylation that connects starvation-responsive metabolism to epigenetic regulation. Sirtuins are a fami...

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Detalles Bibliográficos
Autores principales: Zhang, Xingrun, Cao, Ruili, Niu, Jinrong, Yang, Shumin, Ma, Huida, Zhao, Shuai, Li, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796883/
https://www.ncbi.nlm.nih.gov/pubmed/31636949
http://dx.doi.org/10.1038/s41421-019-0103-0