Structural basis of allosteric regulation of Tel1/ATM kinase

ATM/Tel1 is an apical kinase that orchestrates the multifaceted DNA damage response. Mutations of ATM/Tel1 are associated with ataxia telangiectasia syndrome. Here, we report cryo-EM structures of symmetric dimer (4.1 Å) and asymmetric dimer (4.3 Å) of Saccharomyces cerevisiae Tel1. In the symmetric...

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Detalles Bibliográficos
Autores principales: Xin, Jiyu, Xu, Zhu, Wang, Xuejuan, Tian, Yanhua, Zhang, Zhihui, Cai, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796912/
https://www.ncbi.nlm.nih.gov/pubmed/31097817
http://dx.doi.org/10.1038/s41422-019-0176-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796912/
https://www.ncbi.nlm.nih.gov/pubmed/31097817
http://dx.doi.org/10.1038/s41422-019-0176-1

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