PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila

Ptc is a gatekeeper to avoid abnormal Hh signaling activation, but the key regulators involved in Ptc-mediated inhibition remain largely unknown. Here, we identify PKAc as a key regulator required for Ptc inhibitory function. In the absence of Hh, PKAc physically interacts with Ptc and phosphorylate...

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Detalles Bibliográficos
Autores principales: Fan, Jialin, Gao, Yajie, Lu, Yi, Wu, Wenqing, Yuan, Shuo, Wu, Hailong, Chen, Dahua, Zhao, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796939/
https://www.ncbi.nlm.nih.gov/pubmed/31636957
http://dx.doi.org/10.1038/s41421-019-0112-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796939/
https://www.ncbi.nlm.nih.gov/pubmed/31636957
http://dx.doi.org/10.1038/s41421-019-0112-z

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