Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

[Image: see text] Proline- and arginine-rich peptide PR11 is an allosteric inhibitor of 20S proteasome. We modified its sequence inter alia by introducing HbYX, RYX, or RHbX C-terminal extensions (Hb, hydrophobic moiety; R, arginine; Y, tyrosine; X, any residue). Consequently, we were able to improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Giżyńska, Małgorzata, Witkowska, Julia, Karpowicz, Przemysław, Rostankowski, Rafał, Chocron, Estrella S., Pickering, Andrew M., Osmulski, Pawel, Gaczynska, Maria, Jankowska, Elżbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796967/
https://www.ncbi.nlm.nih.gov/pubmed/30452262
http://dx.doi.org/10.1021/acs.jmedchem.8b01025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796967/
https://www.ncbi.nlm.nih.gov/pubmed/30452262
http://dx.doi.org/10.1021/acs.jmedchem.8b01025

Ejemplares similares