FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3

Adult granulosa cell tumor (aGCT) is a rare type of ovarian cancer characterized by estrogen excess. Interestingly, only the single somatic mutation FOXL2(C134W) was found across virtually all aGCTs. We previously reported that FOXL2(C134W) stimulates CYP19 transcription synergistically with SMAD3,...

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Detalles Bibliográficos
Autores principales: Belli, Martina, Secchi, Christian, Stupack, Dwayne, Shimasaki, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797057/
https://www.ncbi.nlm.nih.gov/pubmed/31701078
http://dx.doi.org/10.1210/js.2019-00279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797057/
https://www.ncbi.nlm.nih.gov/pubmed/31701078
http://dx.doi.org/10.1210/js.2019-00279

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