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FOXO1 Negates the Cooperative Action of FOXL2(C134W) and SMAD3 in CYP19 Expression in HGrC1 Cells by Sequestering SMAD3
Adult granulosa cell tumor (aGCT) is a rare type of ovarian cancer characterized by estrogen excess. Interestingly, only the single somatic mutation FOXL2(C134W) was found across virtually all aGCTs. We previously reported that FOXL2(C134W) stimulates CYP19 transcription synergistically with SMAD3,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Endocrine Society
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797057/ https://www.ncbi.nlm.nih.gov/pubmed/31701078 http://dx.doi.org/10.1210/js.2019-00279 |