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Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry

We report the analysis of a complex enveloped human virus, herpes simplex virus (HSV), assembled after in vivo incorporation of bio-orthogonal methionine analogues homopropargylglycine (HPG) or azidohomoalanine (AHA). We optimised protocols for the production of virions incorporating AHA (termed HSV...

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Detalles Bibliográficos
Autores principales: Serwa, Remigiusz A., Sekine, Eiki, Brown, Jonathan, Teo, Su Hui Catherine, Tate, Edward W., O’Hare, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797222/
https://www.ncbi.nlm.nih.gov/pubmed/31589653
http://dx.doi.org/10.1371/journal.ppat.1007956