Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

The cAMP-dependent protein kinase A (PKA) regulates various cellular functions in health and disease. In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation. Here, we used a chemical genetic screen to identify endothelial-specific direct substrates of PKA in human...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaocheng, Nedvetsky, Pavel, Stanchi, Fabio, Vion, Anne-Clemence, Popp, Oliver, Zühlke, Kerstin, Dittmar, Gunnar, Klussmann, Enno, Gerhardt, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797479/
https://www.ncbi.nlm.nih.gov/pubmed/31580256
http://dx.doi.org/10.7554/eLife.46380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797479/
https://www.ncbi.nlm.nih.gov/pubmed/31580256
http://dx.doi.org/10.7554/eLife.46380

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