Cargando…

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

The cAMP-dependent protein kinase A (PKA) regulates various cellular functions in health and disease. In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation. Here, we used a chemical genetic screen to identify endothelial-specific direct substrates of PKA in human...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Xiaocheng, Nedvetsky, Pavel, Stanchi, Fabio, Vion, Anne-Clemence, Popp, Oliver, Zühlke, Kerstin, Dittmar, Gunnar, Klussmann, Enno, Gerhardt, Holger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797479/ https://www.ncbi.nlm.nih.gov/pubmed/31580256 http://dx.doi.org/10.7554/eLife.46380

Ejemplares similares

Correction: Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1
por: Zhao, Xiaocheng, et al.
Publicado: (2020)

Structures of PKA–phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy
por: Qin, Juan, et al.
Publicado: (2022)

The autophagic membrane tether ATG2A transfers lipids between membranes
por: Maeda, Shintaro, et al.
Publicado: (2019)

Bimodal antagonism of PKA signalling by ARHGAP36
por: Eccles, Rebecca L., et al.
Publicado: (2016)

Spatially compartmentalized phase regulation of a Ca(2+)-cAMP-PKA oscillatory circuit
por: Tenner, Brian, et al.
Publicado: (2020)

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s
por: Zhang, Wenxin, et al.
Publicado: (2023)

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
por: Koudelková, Lenka, et al.
Publicado: (2023)

Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb
por: Mayfield, Joshua E, et al.
Publicado: (2019)

Vascular and Liver Homeostasis in Juvenile Mice Require Endothelial Cyclic AMP-Dependent Protein Kinase A
por: Nedvetsky, Pavel I., et al.
Publicado: (2022)

Serine phosphorylation regulates the P-type potassium pump KdpFABC
por: Sweet, Marie E, et al.
Publicado: (2020)

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb
por: Huang, Fang, et al.
Publicado: (2021)

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
por: Hajicek, Nicole, et al.
Publicado: (2019)

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel
por: Mo, Xiaoyi, et al.
Publicado: (2022)

Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release
por: Bibel, Brianna, et al.
Publicado: (2022)

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair
por: Amar-Schwartz, Adi, et al.
Publicado: (2022)

Mechanism of cargo-directed Atg8 conjugation during selective autophagy
por: Fracchiolla, Dorotea, et al.
Publicado: (2016)

Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau
por: Ma, Xiaojuan, et al.
Publicado: (2020)

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
por: Zhang, Shengnan, et al.
Publicado: (2022)

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
por: Steger, Martin, et al.
Publicado: (2017)

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
por: Brian, Ben F, et al.
Publicado: (2019)

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
por: Ramachandran, Anassuya, et al.
Publicado: (2018)

AR phosphorylation and CHK2 kinase activity regulates IR-stabilized AR–CHK2 interaction and prostate cancer survival
por: Ta, Huy Q, et al.
Publicado: (2020)

Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models
por: Ramani, Komal, et al.
Publicado: (2022)

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells
por: Zhang, Yanchun, et al.
Publicado: (2022)

Correction: Targeting A-kinase anchoring protein 12 phosphorylation in hepatic stellate cells regulates liver injury and fibrosis in mouse models
por: Ramani, Komal, et al.
Publicado: (2023)

Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in Aedes albopictus
por: Qiao, Jialu, et al.
Publicado: (2018)

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
por: Hu, Xuchen, et al.
Publicado: (2019)

The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding
por: Kudva, Renuka, et al.
Publicado: (2018)

The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions
por: Mertins, Jasmin, et al.
Publicado: (2021)

A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells
por: Noor, Sina Ibne, et al.
Publicado: (2018)

Residue-by-residue analysis of cotranslational membrane protein integration in vivo
por: Nicolaus, Felix, et al.
Publicado: (2021)

Structural and mutational analysis of the ribosome-arresting human XBP1u
por: Shanmuganathan, Vivekanandan, et al.
Publicado: (2019)

Processing of the ribosomal ubiquitin-like fusion protein FUBI-eS30/FAU is required for 40S maturation and depends on USP36
por: van den Heuvel, Jasmin, et al.
Publicado: (2021)

Structure and topology around the cleavage site regulate post-translational cleavage of the HIV-1 gp160 signal peptide
por: Snapp, Erik Lee, et al.
Publicado: (2017)

Pathogenic PS1 phosphorylation at Ser367
por: Maesako, Masato, et al.
Publicado: (2017)

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP–PKA Interactions**
por: Schäfer, Gesa, et al.
Publicado: (2013)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, Matthew E, et al.
Publicado: (2019)

Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa
por: Bleffert, Florian, et al.
Publicado: (2022)

Combinative effects of β-elemene and propranolol on the proliferation, migration, and angiogenesis of hemangioma
por: Wang, Zhenyu, et al.
Publicado: (2023)

Cyclin D activates the Rb tumor suppressor by mono-phosphorylation
por: Narasimha, Anil M, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c2mdti99gj7ptfmuucr0hspkfk