Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics

The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in animal models of pain. Here, we have used functio...

Descripción completa

Detalles Bibliográficos
Autores principales: Mostyn, Shannon N, Wilson, Katie A, Schumann-Gillett, Alexandra, Frangos, Zachary J, Shimmon, Susan, Rawling, Tristan, Ryan, Renae M, O'Mara, Megan L, Vandenberg, Robert J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797481/
https://www.ncbi.nlm.nih.gov/pubmed/31621581
http://dx.doi.org/10.7554/eLife.47150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797481/
https://www.ncbi.nlm.nih.gov/pubmed/31621581
http://dx.doi.org/10.7554/eLife.47150

Ejemplares similares