Cargando…

A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma

PURPOSE: The overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC). METHODS: We evaluated associations of common variants in PLK4 and its promoter...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Lijuan, Zhou, Yan, Ju, Sihan, Han, Jing, Song, Ci, Kong, Jing, Wu, Yifei, Lu, Shuai, Xu, Jiani, Yuan, Wenwen, Zhang, Erbao, Wang, Cheng, Hu, Zhibin, Gu, Yayun, Luo, Rongcheng, Wang, Xuehao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Cancer Prevention
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797585/ https://www.ncbi.nlm.nih.gov/pubmed/31489978 http://dx.doi.org/10.1002/cam4.2487

Ejemplares similares

PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types
por: Gong, Jing, et al.
Publicado: (2018)

Robust Linear Models for Cis-eQTL Analysis
por: Rantalainen, Mattias, et al.
Publicado: (2015)

Mining the role of angiopoietin‐like protein family in gastric cancer and seeking potential therapeutic targets by integrative bioinformatics analysis
por: Tang, Cheng, et al.
Publicado: (2020)

Hepatitis B virus mutations, expression quantitative trait loci for PTPN12, and their interactions in hepatocellular carcinoma
por: Song, Ci, et al.
Publicado: (2016)

Genetic variants within microRNA‐binding site of RAD51B are associated with risk of cervical cancer in Chinese women
por: Hang, Dong, et al.
Publicado: (2016)

A novel plasma circular RNA circFARSA is a potential biomarker for non‐small cell lung cancer
por: Hang, Dong, et al.
Publicado: (2018)

Meta-eQTL: a tool set for flexible eQTL meta-analysis
por: Di Narzo, Antonio Fabio, et al.
Publicado: (2014)

Cis-eQTL Analysis and Functional Validation of Candidate Genes for Carcass Yield Traits in Beef Cattle
por: Wang, Tianzhen, et al.
Publicado: (2022)

Gene amplification derived a cancer‐testis long noncoding RNA PCAT6 regulates cell proliferation and migration in hepatocellular carcinoma
por: Chen, Shuaizhou, et al.
Publicado: (2019)

Potentially functional polymorphisms in PAK1 are associated with risk of lung cancer in a Chinese population
por: Zheng, Mingfeng, et al.
Publicado: (2015)

Mitochondrial DNA copy number is associated with risk of head and neck squamous cell carcinoma in Chinese population
por: Wang, Lihua, et al.
Publicado: (2018)

Systematic Genetic Analysis Identifies Cis-eQTL Target Genes Associated with Glioblastoma Patient Survival
por: Chen, Qing-Rong, et al.
Publicado: (2014)

A cis-eQTL of HLA-DPB1 Affects Susceptibility to Type 1 Autoimmune Hepatitis
por: Yamazaki, Tomoo, et al.
Publicado: (2018)

In silico pathway analysis and tissue specific cis-eQTL for colorectal cancer GWAS risk variants
por: Loo, Lenora W. M., et al.
Publicado: (2017)

A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data
por: Lamparter, David, et al.
Publicado: (2020)

Genetic variants of SP‐D confer susceptibility to radiation pneumonitis in lung cancer patients undergoing thoracic radiation therapy
por: Xu, Li, et al.
Publicado: (2019)

Reveal—visual eQTL analytics
por: Jäger, Günter, et al.
Publicado: (2012)

Risk factors for brain metastases in patients with non–small‐cell lung cancer
por: An, Ning, et al.
Publicado: (2018)

Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer
por: Li, Dan, et al.
Publicado: (2016)

Genome-wide QTL and eQTL analyses using Mendel
por: Zhou, Hua, et al.
Publicado: (2016)

Spatial distribution characteristics of tumor marker CA724 reference values in China
por: Jing, Jing, et al.
Publicado: (2019)

Recurrent patterns after postoperative radiotherapy for early stage endometrial cancer: A competing risk analysis model
por: Ren, Kang, et al.
Publicado: (2021)

Telomere length in cervical exfoliated cells, interaction with HPV genotype, and cervical cancer occurrence among high‐risk HPV‐positive women
por: Chen, Xiaojun, et al.
Publicado: (2019)

Role of serum EBV‐VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population
por: Wang, Zeyang, et al.
Publicado: (2018)

Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis
por: Guo, Chenyu, et al.
Publicado: (2019)

Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer
por: Lawrenson, Kate, et al.
Publicado: (2015)

How spatial accessibility to colonoscopy affects diagnostic adherences and adverse intestinal outcomes among the patients with positive preliminary screening findings
por: Chen, Weiyi, et al.
Publicado: (2020)

Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma Using cis-eQTL Analysis
por: Kim, Jihye, et al.
Publicado: (2020)

Predictive model for risk of gastric cancer using genetic variants from genome‐wide association studies and high‐evidence meta‐analysis
por: Qiu, Lixin, et al.
Publicado: (2020)

Mendelian randomization study of telomere length and lung cancer risk in East Asian population
por: Cao, Xuguang, et al.
Publicado: (2019)

A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study
por: Chen, Fa, et al.
Publicado: (2018)

Genetic correction of serum AFP level improves risk prediction of primary hepatocellular carcinoma in the Dongfeng–Tongji cohort study
por: Wang, Ke, et al.
Publicado: (2018)

eQTL Epistasis – Challenges and Computational Approaches
por: Huang, Yang, et al.
Publicado: (2013)

Genomic, transcriptomic, and viral integration profiles associated with recurrent/metastatic progression in high‐risk human papillomavirus cervical carcinomas
por: Liu, Jing Jing, et al.
Publicado: (2020)

Serum uric acid levels and risk of kidney cancer incidence and mortality: A prospective cohort study
por: Dai, Xiao‐Yu, et al.
Publicado: (2020)

SNP eQTL status and eQTL density in the adjacent region of the SNP are associated with its statistical significance in GWA studies
por: Gorlov, Ivan, et al.
Publicado: (2019)

Risk factors for level V lymph node metastases in solitary papillary thyroid carcinoma with clinically lateral lymph node metastases
por: Yang, Jing, et al.
Publicado: (2016)

A genetic variant in miR‐100 is a protective factor of childhood acute lymphoblastic leukemia
por: Xue, Yao, et al.
Publicado: (2019)

Proteomics reveals the function reverse of MPSSS‐treated prostate cancer‐associated fibroblasts to suppress PC‐3 cell viability via the FoxO pathway
por: Zhang, Tingting, et al.
Publicado: (2021)

Incidence proportions and prognosis of breast cancer patients with bone metastases at initial diagnosis
por: Gong, Yue, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_0u9e8m8r66jiar3qgkg51d3at0