Low pH Exposure During Immunoglobulin G Purification Methods Results in Aggregates That Avidly Bind Fcγ Receptors: Implications for Measuring Fc Dependent Antibody Functions

Evaluating the biophysical and functional nature of IgG is key to defining correlates of protection in infectious disease, and autoimmunity research cohorts, as well as vaccine efficacy trials. These studies often require small quantities of IgG to be purified from plasma for downstream analysis wit...

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Detalles Bibliográficos
Autores principales: Lopez, Ester, Scott, Nichollas E., Wines, Bruce D., Hogarth, P. Mark, Wheatley, Adam K., Kent, Stephen J., Chung, Amy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797627/
https://www.ncbi.nlm.nih.gov/pubmed/31681303
http://dx.doi.org/10.3389/fimmu.2019.02415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797627/
https://www.ncbi.nlm.nih.gov/pubmed/31681303
http://dx.doi.org/10.3389/fimmu.2019.02415

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