Absorption, Distribution, and Binding Profile of ME-401, a Potent and Selective Oral Small-Molecule Inhibitor of Phosphatidylinositol 3-Kinase δ (PI3Kδ) in Animal and B-Cell Lymphoma Models

BACKGROUND: Phosphatidylinositol 3-kinase isoform δ (PI3Kδ) mediates multiple events in lymphocytes, including cell proliferation, survival, and motility. Inhibition of PI3Kδ, with downstream inhibitory effects on cell growth and survival, has been utilized to treat lymphoid malignancies. ME-401 is...

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Detalles Bibliográficos
Autores principales: Moreno, Ofir, Wood, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797648/
https://www.ncbi.nlm.nih.gov/pubmed/31506873
http://dx.doi.org/10.1007/s11523-019-00668-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797648/
https://www.ncbi.nlm.nih.gov/pubmed/31506873
http://dx.doi.org/10.1007/s11523-019-00668-y

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