Loss of TIMP3 by promoter methylation of Sp1 binding site promotes oral cancer metastasis

The tissue inhibitor of metalloproteinase-3 (TIMP3) is the only member of the TIMP family that binds to the extracellular matrix and suppresses cancer cell growth, angiogenesis, migration, and invasion. However, whether the abnormal expression and promoter methylation of TIMP3 facilitates oral cance...

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Detalles Bibliográficos
Autores principales: Su, Chun-Wen, Chang, Yu-Chao, Chien, Ming-Hsien, Hsieh, Yi-Hsien, Chen, Mu-Kuan, Lin, Chiao-Wen, Yang, Shun-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797751/
https://www.ncbi.nlm.nih.gov/pubmed/31624299
http://dx.doi.org/10.1038/s41419-019-2016-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797751/
https://www.ncbi.nlm.nih.gov/pubmed/31624299
http://dx.doi.org/10.1038/s41419-019-2016-0

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