Strategies to reduce genetic mosaicism following CRISPR-mediated genome edition in bovine embryos

Genetic mosaicism is the presence of more than two alleles on an individual and it is commonly observed following CRISPR microinjection of zygotes. This phenomenon appears when DNA replication precedes CRISPR-mediated genome edition and it is undesirable because it reduces greatly the odds for direc...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamas-Toranzo, I., Galiano-Cogolludo, B., Cornudella-Ardiaca, F., Cobos-Figueroa, J., Ousinde, O., Bermejo-Álvarez, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797768/
https://www.ncbi.nlm.nih.gov/pubmed/31624292
http://dx.doi.org/10.1038/s41598-019-51366-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797768/
https://www.ncbi.nlm.nih.gov/pubmed/31624292
http://dx.doi.org/10.1038/s41598-019-51366-8

Ejemplares similares