Janus Kinase 1 Is Required for Transcriptional Reprograming of Murine Astrocytes in Response to Endoplasmic Reticulum Stress

Neurodegenerative diseases are associated with the accumulation of misfolded proteins in the endoplasmic reticulum (ER), leading to ER stress. To adapt, cells initiate the unfolded protein response (UPR). However, severe or unresolved UPR activation leads to cell death and inflammation. The UPR is i...

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Detalles Bibliográficos
Autores principales: Sims, Savannah G., Meares, Gordon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797841/
https://www.ncbi.nlm.nih.gov/pubmed/31680865
http://dx.doi.org/10.3389/fncel.2019.00446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797841/
https://www.ncbi.nlm.nih.gov/pubmed/31680865
http://dx.doi.org/10.3389/fncel.2019.00446

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