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Increased Incidence of Colon Tumors in AOM-Treated Apc(1638N/+) Mice Reveals Higher Frequency of Tumor Associated Neutrophils in Colon Than Small Intestine
Colorectal cancer (CRC) is one of the most common cancers and a major cause of mortality. Mice with truncating Apc germline mutations have been used as a standard model of CRC, but most of the Apc-mutated lines develop multiple tumors in the proximal small intestine and rarely in the colon precludin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797844/ https://www.ncbi.nlm.nih.gov/pubmed/31681563 http://dx.doi.org/10.3389/fonc.2019.01001 |