Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation

BACKGROUND: While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal cancer. Activation of the WNT pathway ultimately leads to the nuclear translocat...

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Detalles Bibliográficos
Autores principales: Hao, Yi-Heng, Lafita-Navarro, M. Carmen, Zacharias, Lauren, Borenstein-Auerbach, Nofit, Kim, Min, Barnes, Spencer, Kim, Jiwoong, Shay, Jerry, DeBerardinis, Ralph J., Conacci-Sorrell, Maralice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798382/
https://www.ncbi.nlm.nih.gov/pubmed/31623618
http://dx.doi.org/10.1186/s12964-019-0444-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798382/
https://www.ncbi.nlm.nih.gov/pubmed/31623618
http://dx.doi.org/10.1186/s12964-019-0444-1

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