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Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome

Dravet syndrome is a life-threatening early-onset epilepsy not well controlled by antiepileptic drugs. Drugs that modulate serotonin (5-HT) signalling, including clemizole, locaserin, trazodone and fenfluramine, have recently emerged as potential treatment options for Dravet syndrome. To investigate...

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Detalles Bibliográficos
Autores principales: Griffin, Aliesha L, Jaishankar, Priyadarshini, Grandjean, Jean-Marc, Olson, Steven H, Renslo, Adam R, Baraban, Scott C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798786/
https://www.ncbi.nlm.nih.gov/pubmed/31667472
http://dx.doi.org/10.1093/braincomms/fcz008