Mutations in RHOT1 Disrupt Endoplasmic Reticulum–Mitochondria Contact Sites Interfering with Calcium Homeostasis and Mitochondrial Dynamics in Parkinson's Disease

Aims: The outer mitochondrial membrane protein Miro1 is a crucial player in mitochondrial dynamics and calcium homeostasis. Recent evidence indicated that Miro1 mediates calcium-induced mitochondrial shape transition, which is a prerequisite for the initiation of mitophagy. Moreover, altered Miro1 p...

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Detalles Bibliográficos
Autores principales: Grossmann, Dajana, Berenguer-Escuder, Clara, Bellet, Marie Estelle, Scheibner, David, Bohler, Jill, Massart, Francois, Rapaport, Doron, Skupin, Alexander, Fouquier d'Hérouël, Aymeric, Sharma, Manu, Ghelfi, Jenny, Raković, Aleksandar, Lichtner, Peter, Antony, Paul, Glaab, Enrico, May, Patrick, Dimmer, Kai Stefan, Fitzgerald, Julia Catherine, Grünewald, Anne, Krüger, Rejko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798875/
https://www.ncbi.nlm.nih.gov/pubmed/31303019
http://dx.doi.org/10.1089/ars.2018.7718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798875/
https://www.ncbi.nlm.nih.gov/pubmed/31303019
http://dx.doi.org/10.1089/ars.2018.7718

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