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2467 PRMT5 is a master epigenetic regulator to promote repair of radiation-induced DNA damage
OBJECTIVES/SPECIFIC AIMS: We recently reported that PRMT5 epigenetically activates androgen receptor (AR) in prostate cancer cells. Because targeting AR signaling through androgen deprivation therapy is clinically used as a radiosensitization approach to treat high-risk prostate cancer, our finding...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cambridge University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798993/ http://dx.doi.org/10.1017/cts.2018.109 |