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3348 Structural Determinants of Neoantigen Immunogenicity for Cancer Therapy

OBJECTIVES/SPECIFIC AIMS: We are exploring the structure of the interaction between an immunogenic neoantigen and a T cell receptor (TCR) that recognizes the neoantigen while tolerating the counterpart self antigen. No structural example exists to date of how a TCR can discriminate between a neoanti...

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Detalles Bibliográficos
Autores principales: Devlin, Jason, Bobisse, Sara, Harari, Alexandre, Baker, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799638/
http://dx.doi.org/10.1017/cts.2019.54