Cargando…

2337: Doxorubicin exposure in vitro stimulates ROS production and directly suppresses cardiac fibroblast proliferation

OBJECTIVES/SPECIFIC AIMS: Our research strives to understand the pathophysiology of doxorubicin cardiotoxicity, focusing on the understudied nonmyocyte cardiac cells. Our understanding will enable researchers to develop protective or alternative therapies for cancer patients and treatments for cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mancilla, Trevi A., Aune, Gregory J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Basic Science/Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799773/ http://dx.doi.org/10.1017/cts.2017.41

Ejemplares similares

Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts
por: Mancilla, T. R., et al.
Publicado: (2020)

Tissue-protective activity of selenomethionine and D-panthetine in B16 melanoma-bearing mice under doxorubicin treatment is not connected with their ROS scavenging potential
por: Panchuk, Rostyslav R., et al.
Publicado: (2017)

2373: Effects of cortical stimulation of the noninfarcted Versus peri-infarcted motor cortex
por: Kinley-Cooper, Serena-Kaye, et al.
Publicado: (2018)

PReS-FINAL-2337: The eurofever registry: 3 years of enrollment
por: Federici, S, et al.
Publicado: (2013)

Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells
por: Cao, Guo-Jun, et al.
Publicado: (2021)

Angiotensin II suppresses osteoblastic differentiation and mineralized nodule formation via AT(1) receptor in ROS17/2.8 cells
por: Nakai, Kumiko, et al.
Publicado: (2015)

4072 Optimizing ex-vivo perfusion in Vascularized Composite Allotransplantation using Hyperosmolar solution and Electric Stimulation: Preliminary Results
por: Jonczyk, Michael, et al.
Publicado: (2020)

Neutrophil elastase stimulates MUC5AC expression in human biliary epithelial cells: a possible pathway of PKC/Nox/ROS
por: Tian, Yu, et al.
Publicado: (2017)

The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
por: Cheng, Yinwen, et al.
Publicado: (2021)

Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells
por: Richardson, Gavin David, et al.
Publicado: (2018)

4447 Leptin supplementation prevents the loss of hypoglycemia-induced glucagon release following exposure to six days of severe caloric restriction in mice
por: McDougal, David H, et al.
Publicado: (2020)

FK506-binding protein 5 inhibits proliferation and stimulates apoptosis of glioma cells
por: Yang, Hui, et al.
Publicado: (2015)

Phosphotyrosine picked threonine kinase stimulates proliferation of human osteosarcoma cells in vitro and in vivo
por: Wang, Zhe-Xiang, et al.
Publicado: (2021)

A comparison of genomic copy number calls by Partek Genomics Suite, Genotyping Console and Birdsuite algorithms to quantitative PCR
por: Grayson, Britney L, et al.
Publicado: (2011)

Optimization and evaluation of surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry for protein profiling of cerebrospinal fluid
por: Guerreiro, Nelson, et al.
Publicado: (2006)

TLR8 agonist VTX-2337 enhances NKG2D-mediated cytotoxicity of NK cells
por: Lu, Hailing, et al.
Publicado: (2013)

Small Interfering RNA–Mediated Suppression of Fas Modulate Apoptosis and Proliferation in Rat Intervertebral Disc Cells
por: Park, Jong-Beom, et al.
Publicado: (2017)

MicroRNA-325 targets lipocalin 15 to suppress proliferation, migration and invasion of breast cancer cells
por: Liu, Zhuangkai, et al.
Publicado: (2020)

4053 A TL1 Team Approach to CNS-Localized Delivery of Glial Cell-Derived Neurotrophic Factor for Treatment of Parkinson’s Disease
por: Farhadi, Shaheen, et al.
Publicado: (2020)

4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE
por: Luongo, Timothy, et al.
Publicado: (2020)

Tumor-associated fibroblasts promote the proliferation and decrease the doxorubicin sensitivity of liposarcoma cells
por: HARATI, KAMRAN, et al.
Publicado: (2016)

Aluminium sulphate exposure increases oxidative stress and suppresses brain development in Ross broiler chicks
por: Oğuz, Emin Oğuzhan, et al.
Publicado: (2012)

Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis
por: Yue, Yuan, et al.
Publicado: (2015)

Cesium suppresses fibroblast proliferation and migration
por: Khatun, Ziasmin, et al.
Publicado: (2020)

A Versatile PDA(DOX) Nanoplatform for Chemo-Photothermal Synergistic Therapy against Breast Cancer and Attenuated Doxorubicin-Induced Cardiotoxicity
por: Geng, Siqi, et al.
Publicado: (2023)

Protective effect of bilberry (Vaccinium myrtillus) against doxorubicin-induced oxidative cardiotoxicity in rats
por: Ashour, Osama M., et al.
Publicado: (2011)

Triolein emulsion infusion into the hepatic artery increases vascular permeability to doxorubicin in rabbit liver
por: Kim, Yong-Woo, et al.
Publicado: (2021)

Development of a miniaturized stimulation device for electrical stimulation of cells
por: Xiong, Gordon Minru, et al.
Publicado: (2015)

Proteome alteration induced by hTERT transfection of human fibroblast cells
por: Mazzucchelli, Gabriel D, et al.
Publicado: (2008)

MiR-34a overexpression enhances the inhibitory effect of doxorubicin on HepG2 cells
por: Zheng, Shun-Zhen, et al.
Publicado: (2019)

High-frequency electrical stimulation in the nucleus accumbens of morphine-treated rats suppresses neuronal firing in reward-related brain regions
por: Hu, Wen-han, et al.
Publicado: (2011)

PAQR3 inhibits proliferation via suppressing PI3K/AKT signaling pathway in non-small cell lung cancer
por: Li, Xiaohui, et al.
Publicado: (2017)

MicroRNA-490-3p suppresses hepatocellular carcinoma cell proliferation and migration by targeting the aurora kinase A gene (AURKA)
por: Zhang, Hui, et al.
Publicado: (2019)

Comparison of ropivacaine and fentanyl toxicity in human fibroblasts
por: Ficklscherer, Andreas, et al.
Publicado: (2013)

Trend tests for the evaluation of exposure-response relationships in epidemiological exposure studies
por: Hothorn, Ludwig A, et al.
Publicado: (2009)

Comparing Current Steering Technologies for Directional Deep Brain Stimulation Using a Computational Model That Incorporates Heterogeneous Tissue Properties
por: Zhang, Simeng, et al.
Publicado: (2019)

Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor
por: Liakouli, Vasiliki, et al.
Publicado: (2018)

Comparison of immune modulation by TLR8 agonist vtx-2337 (motolimod) in cancer patients and healthy volunteers
por: Dietsch, Greg, et al.
Publicado: (2014)

2337. Clinical Characteristics of Children Infected With Macrolide-Resistant Mycoplasma Pneumonia in Central Ohio—Preliminary Data
por: Piazzon, Mariana Lanata, et al.
Publicado: (2018)

2337. Health Outcomes in Congenital Cytomegalovirus, a Systematized and Unbiased Approach in the Electronic Medical Record Era
por: Rochat, Ryan H, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vrjmlg1ajs44la4kgance293pt