Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Alanine-serine-cysteine transporter 2 (ASCT2, SLC1A5) is the primary transporter of glutamine in cancer cells and regulates the mTORC1 signaling pathway. The SLC1A5 function involves finely tuned orchestration of two domain movements that include the substrate-binding transport domain and the scaffo...

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Detalles Bibliográficos
Autores principales: Yu, Xiaodi, Plotnikova, Olga, Bonin, Paul D, Subashi, Timothy A, McLellan, Thomas J, Dumlao, Darren, Che, Ye, Dong, Yin Yao, Carpenter, Elisabeth P, West, Graham M, Qiu, Xiayang, Culp, Jeffrey S, Han, Seungil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800002/
https://www.ncbi.nlm.nih.gov/pubmed/31580259
http://dx.doi.org/10.7554/eLife.48120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800002/
https://www.ncbi.nlm.nih.gov/pubmed/31580259
http://dx.doi.org/10.7554/eLife.48120

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