Ctf4 organizes sister replisomes and Pol α into a replication factory

The current view is that eukaryotic replisomes are independent. Here we show that Ctf4 tightly dimerizes CMG helicase, with an extensive interface involving Psf2, Cdc45, and Sld5. Interestingly, Ctf4 binds only one Pol α-primase. Thus, Ctf4 may have evolved as a trimer to organize two helicases and...

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Detalles Bibliográficos
Autores principales: Yuan, Zuanning, Georgescu, Roxana, Santos, Ruda de Luna Almeida, Zhang, Daniel, Bai, Lin, Yao, Nina Y, Zhao, Gongpu, O'Donnell, Michael E, Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800005/
https://www.ncbi.nlm.nih.gov/pubmed/31589141
http://dx.doi.org/10.7554/eLife.47405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800005/
https://www.ncbi.nlm.nih.gov/pubmed/31589141
http://dx.doi.org/10.7554/eLife.47405

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