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A 3D Human Tri-Culture System Modeling Neurodegeneration and Neuroinflammation in Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized by beta-amyloid (Aβ) accumulation, phosphorylated tau (p-tau) formation, hyper-activation of glial cells, and neuronal loss. The mechanisms of AD pathogenesis, however, remain poorly understood partially due to the lack of relevant human models that can comp...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800152/ https://www.ncbi.nlm.nih.gov/pubmed/29950669 http://dx.doi.org/10.1038/s41593-018-0175-4 |