Non-canonical translation via deadenylated 3′UTRs maintains primordial germ cells

Primordial germ cells (PGCs) form during early embryogenesis with a supply of maternal mRNAs that contain shorter poly(A)-tails. How translation of maternal mRNAs is regulated during PGC development remains elusive. Here we describe a small molecule screen with zebrafish embryos that identified prim...

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Detalles Bibliográficos
Autores principales: Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800240/
https://www.ncbi.nlm.nih.gov/pubmed/29988067
http://dx.doi.org/10.1038/s41589-018-0098-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800240/
https://www.ncbi.nlm.nih.gov/pubmed/29988067
http://dx.doi.org/10.1038/s41589-018-0098-0

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