Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) catalyze the dynamic and reversible acetylation of proteins, an epigenetic regulatory mechanism associated with multiple cancers. Indeed, HDAC inhibitors are already approved in the clinic. The HAT paralogs p300 and CREB-binding prot...

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Detalles Bibliográficos
Autores principales: Gardberg, Anna S., Huhn, Annissa J., Cummings, Richard, Bommi-Reddy, Archana, Poy, Florence, Setser, Jeremy, Vivat, Valerie, Brucelle, Francois, Wilson, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Crystallographic Association 2019
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800282/
https://www.ncbi.nlm.nih.gov/pubmed/31649965
http://dx.doi.org/10.1063/1.5119336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800282/
https://www.ncbi.nlm.nih.gov/pubmed/31649965
http://dx.doi.org/10.1063/1.5119336

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