Sialic acid mediated mechanical activation of β(2) adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β(2) adrenergic receptor (β(2)AR) to cause meningitis in humans. Molecular mechanisms of receptor activation by the pathogen and of its species selectivity remained elusive. We report that β(2)AR activation requires two aspar...

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Detalles Bibliográficos
Autores principales: Virion, Zoe, Doly, Stéphane, Saha, Kusumika, Lambert, Mireille, Guillonneau, François, Bied, Camille, Duke, Rebecca M., Rudd, Pauline M., Robbe-Masselot, Catherine, Nassif, Xavier, Coureuil, Mathieu, Marullo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800425/
https://www.ncbi.nlm.nih.gov/pubmed/31628314
http://dx.doi.org/10.1038/s41467-019-12685-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800425/
https://www.ncbi.nlm.nih.gov/pubmed/31628314
http://dx.doi.org/10.1038/s41467-019-12685-6

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