Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates

The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. Here, we investigated [(68)Ga]Ga-DO3A-S01-GCG as a bioma...

Descripción completa

Detalles Bibliográficos
Autores principales: Eriksson, Olof, Velikyan, Irina, Haack, Torsten, Bossart, Martin, Evers, Andreas, Laitinen, Iina, Larsen, Philip J., Plettenburg, Oliver, Takano, Akihiro, Halldin, Christer, Antoni, Gunnar, Johansson, Lars, Pierrou, Stefan, Wagner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800434/
https://www.ncbi.nlm.nih.gov/pubmed/31628379
http://dx.doi.org/10.1038/s41598-019-51530-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800434/
https://www.ncbi.nlm.nih.gov/pubmed/31628379
http://dx.doi.org/10.1038/s41598-019-51530-0

Ejemplares similares