Population pharmacokinetic modeling to facilitate dose selection of tapentadol in the pediatric population

OBJECTIVE: The main aim of this analysis was to characterize the pharmacokinetics (PK) of the strong analgesic tapentadol in 2-year-old to <18-year-old patients with acute pain and to inform the optimal dosing strategy for a confirmatory efficacy trial in this patient population. METHODS: The ana...

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Detalles Bibliográficos
Autores principales: Watson, Estelle, Khandelwal, Akash, Freijer, Jan, van den Anker, John, Lefeber, Claudia, Eerdekens, Mariëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800464/
https://www.ncbi.nlm.nih.gov/pubmed/31686902
http://dx.doi.org/10.2147/JPR.S208454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800464/
https://www.ncbi.nlm.nih.gov/pubmed/31686902
http://dx.doi.org/10.2147/JPR.S208454

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