Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation

BACKGROUND: Repeated failure of drug candidates targeting Alzheimer’s disease (AD) in clinical trials likely stems from a lack of understanding of the molecular mechanisms underlying AD pathogenesis. Recent research has highlighted synergistic interactions between aggregated amyloid-β (Aβ) and tau p...

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Detalles Bibliográficos
Autores principales: Shin, Woo Shik, Di, Jing, Cao, Qin, Li, Binsen, Seidler, Paul M., Murray, Kevin A., Bitan, Gal, Jiang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800506/
https://www.ncbi.nlm.nih.gov/pubmed/31627745
http://dx.doi.org/10.1186/s13195-019-0541-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800506/
https://www.ncbi.nlm.nih.gov/pubmed/31627745
http://dx.doi.org/10.1186/s13195-019-0541-9

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