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Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
BACKGROUND: Repeated failure of drug candidates targeting Alzheimer’s disease (AD) in clinical trials likely stems from a lack of understanding of the molecular mechanisms underlying AD pathogenesis. Recent research has highlighted synergistic interactions between aggregated amyloid-β (Aβ) and tau p...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800506/ https://www.ncbi.nlm.nih.gov/pubmed/31627745 http://dx.doi.org/10.1186/s13195-019-0541-9 |