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Editosome RNase III domain interactions are essential for editing and differ between life cycle stages in Trypanosoma brucei

Multiprotein editosomes catalyze gRNA-specified insertion and deletion of uridines to create functional mitochondrial mRNAs in Trypanosoma brucei. Three functionally distinct editosomes are distinguished by their single KREN1, KREN2, or KREN3 RNase III endonuclease and, respectively, KREPB8, KREPB7,...

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Detalles Bibliográficos
Autores principales: McDermott, Suzanne M., Carnes, Jason, Stuart, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800513/
https://www.ncbi.nlm.nih.gov/pubmed/31171708
http://dx.doi.org/10.1261/rna.071258.119