SplintQuant: a method for accurately quantifying circular RNA transcript abundance without reverse transcription bias

Reverse transcription of RNA is fallible, introducing biases and confounding the quantification of transcript abundance. We demonstrate that circular RNAs (circRNAs) are more subjective to overestimation of transcript abundance than cognate linear RNAs due to their covalently closed, circular form,...

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Detalles Bibliográficos
Autores principales: Conn, Vanessa, Conn, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800515/
https://www.ncbi.nlm.nih.gov/pubmed/31151991
http://dx.doi.org/10.1261/rna.070953.119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800515/
https://www.ncbi.nlm.nih.gov/pubmed/31151991
http://dx.doi.org/10.1261/rna.070953.119

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