MALDI-MS: a Rapid and Reliable Method for Drug-to-Antibody Ratio Determination of Antibody-Drug Conjugates

BACKGROUND: It is believed that the loading value of anticancer drug conjugated to the monoclonal antibody, called drug-to-antibody ratio (DAR), is the main quality feature of antibody-drug conjugates. METHODS: In this study, matrix assisted laser desorption/ionization mass spectrometry was used to...

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Detalles Bibliográficos
Autores principales: Abedi, Mehri, Ahangari Cohan, Reza, Mahboudi, Fereidoun, Shafiee Ardestani, Mehdi, Davami, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2019
Materias:
Full Length
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800535/
https://www.ncbi.nlm.nih.gov/pubmed/31104399
http://dx.doi.org/10.29252/ibj.23.6.395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800535/
https://www.ncbi.nlm.nih.gov/pubmed/31104399
http://dx.doi.org/10.29252/ibj.23.6.395

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