Codon harmonization reduces amino acid misincorporation in bacterially expressed P. falciparum proteins and improves their immunogenicity

Codon usage frequency influences protein structure and function. The frequency with which codons are used potentially impacts primary, secondary and tertiary protein structure. Poor expression, loss of function, insolubility, or truncation can result from species-specific differences in codon usage....

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Detalles Bibliográficos
Autores principales: Punde, Neeraja, Kooken, Jennifer, Leary, Dagmar, Legler, Patricia M., Angov, Evelina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800875/
https://www.ncbi.nlm.nih.gov/pubmed/31630257
http://dx.doi.org/10.1186/s13568-019-0890-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800875/
https://www.ncbi.nlm.nih.gov/pubmed/31630257
http://dx.doi.org/10.1186/s13568-019-0890-6

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