Lycorine Attenuates Autophagy in Osteoclasts via an Axis of mROS/TRPML1/TFEB to Reduce LPS-Induced Bone Loss

Lycorine, a plant alkaloid, exhibits anti-inflammatory activity by acting in macrophages that share precursor cells with osteoclasts (OCs). We hypothesized that lycorine might decrease bone loss by acting in OCs after lipopolysaccharide (LPS) stimulation, since OCs play a main role in LPS-induced bo...

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Detalles Bibliográficos
Autores principales: Park, Hyun-Jung, Gholam-Zadeh, Malihatosadat, Suh, Jae-Hee, Choi, Hye-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800915/
https://www.ncbi.nlm.nih.gov/pubmed/31687088
http://dx.doi.org/10.1155/2019/8982147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800915/
https://www.ncbi.nlm.nih.gov/pubmed/31687088
http://dx.doi.org/10.1155/2019/8982147

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