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Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing
Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the origin of two of these stresses, namely mitochondrial metabolic compromise, associated with reactive oxygen species (ROS) production, and replicative senescence, activated by extreme telomere shortening. We di...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801922/ https://www.ncbi.nlm.nih.gov/pubmed/31597307 http://dx.doi.org/10.3390/ijms20194959 |