BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes

Type 1 diabetes (T1D) results from the progressive loss of pancreatic beta cells as a result of autoimmune destruction. We recently reported that during the natural history of T1D in humans and the female nonobese diabetic (NOD) mouse model, beta cells acquire a senescence-associated secretory pheno...

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Detalles Bibliográficos
Autores principales: Thompson, Peter J., Shah, Ajit, Apostolopolou, Hara, Bhushan, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956/
https://www.ncbi.nlm.nih.gov/pubmed/31561444
http://dx.doi.org/10.3390/ijms20194776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956/
https://www.ncbi.nlm.nih.gov/pubmed/31561444
http://dx.doi.org/10.3390/ijms20194776

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