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BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes

Type 1 diabetes (T1D) results from the progressive loss of pancreatic beta cells as a result of autoimmune destruction. We recently reported that during the natural history of T1D in humans and the female nonobese diabetic (NOD) mouse model, beta cells acquire a senescence-associated secretory pheno...

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Detalles Bibliográficos
Autores principales:	Thompson, Peter J., Shah, Ajit, Apostolopolou, Hara, Bhushan, Anil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956/ https://www.ncbi.nlm.nih.gov/pubmed/31561444 http://dx.doi.org/10.3390/ijms20194776

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