Mathematical model of hypoxia and tumor signaling interplay reveals the importance of hypoxia and cell-to-cell variability in tumor growth inhibition

BACKGROUND: Human tumor is a complex tissue with multiple heterogeneous hypoxic regions and significant cell-to-cell variability. Due to the complexity of the disease, the explanation of why anticancer therapies fail cannot be attributed to intrinsic or acquired drug resistance alone. Furthermore, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Emile P., Song, Roy S., Chen, Xueer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802183/
https://www.ncbi.nlm.nih.gov/pubmed/31638911
http://dx.doi.org/10.1186/s12859-019-3098-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802183/
https://www.ncbi.nlm.nih.gov/pubmed/31638911
http://dx.doi.org/10.1186/s12859-019-3098-5

Ejemplares similares