The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthesis and a well-established activator of AMP-activated protein kinase (AMPK), induces widespread metabolic alterations...

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Detalles Bibliográficos
Autores principales: Dembitz, Vilma, Tomic, Barbara, Kodvanj, Ivan, Simon, Julian A., Bedalov, Antonio, Visnjic, Dora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802504/
https://www.ncbi.nlm.nih.gov/pubmed/31431503
http://dx.doi.org/10.1074/jbc.RA119.009396

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802504/
https://www.ncbi.nlm.nih.gov/pubmed/31431503
http://dx.doi.org/10.1074/jbc.RA119.009396

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