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The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion

Metabolic pathways play important roles in proliferation and differentiation of malignant cells. 5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr), a precursor in purine biosynthesis and a well-established activator of AMP-activated protein kinase (AMPK), induces widespread metabolic alterations...

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Detalles Bibliográficos
Autores principales:	Dembitz, Vilma, Tomic, Barbara, Kodvanj, Ivan, Simon, Julian A., Bedalov, Antonio, Visnjic, Dora
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2019
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802504/ https://www.ncbi.nlm.nih.gov/pubmed/31431503 http://dx.doi.org/10.1074/jbc.RA119.009396

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