Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies

Protein ubiquitination and SUMOylation are required for the maintenance of cellular protein homeostasis, and both increase in proteotoxic conditions (e.g. heat shock or proteasome inhibition). However, we found that when ubiquitination was blocked in several human cell lines by inhibiting the ubiqui...

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Detalles Bibliográficos
Autores principales: Sha, Zhe, Blyszcz, Tamara, González-Prieto, Román, Vertegaal, Alfred C. O., Goldberg, Alfred L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802522/
https://www.ncbi.nlm.nih.gov/pubmed/31285264
http://dx.doi.org/10.1074/jbc.RA119.009147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802522/
https://www.ncbi.nlm.nih.gov/pubmed/31285264
http://dx.doi.org/10.1074/jbc.RA119.009147

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