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E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
The human genome is constantly exposed to both endogenous and exogenous stresses, which can lead to errors in DNA replication and the accumulation of DNA mutations, thereby increasing the risk of cancer development. The transcription factor E2F1 is a key regulator of DNA repair. E2F1 also has define...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802646/ https://www.ncbi.nlm.nih.gov/pubmed/31534120 http://dx.doi.org/10.1038/s12276-019-0307-2 |