IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes: JAKinibs suppress the interferon response in RA-FLSs

Rheumatoid arthritis (RA) is an autoimmune disease characterized by persistent synovial inflammation. The major drivers of synovial inflammation are cytokines and chemokines. Among these molecules, TNF activates fibroblast-like synoviocytes (FLSs), which leads to the production of inflammatory media...

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Detalles Bibliográficos
Autores principales: Bonelli, Michael, Dalwigk, Karolina, Platzer, Alexander, Olmos Calvo, Isabel, Hayer, Silvia, Niederreiter, Birgit, Holinka, Johannes, Sevelda, Florian, Pap, Thomas, Steiner, Günter, Superti-Furga, Giulio, Smolen, Josef S., Kiener, Hans P., Karonitsch, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802656/
https://www.ncbi.nlm.nih.gov/pubmed/31285419
http://dx.doi.org/10.1038/s12276-019-0267-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802656/
https://www.ncbi.nlm.nih.gov/pubmed/31285419
http://dx.doi.org/10.1038/s12276-019-0267-6

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