Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells

The sodium leak channel NALCN is a key player in establishing the resting membrane potential (RMP) in neurons and transduces changes in extracellular Ca(2+) concentration ([Ca(2+)](e)) into increased neuronal excitability as the downstream effector of calcium-sensing receptor (CaSR). Gain-of-functio...

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Detalles Bibliográficos
Autores principales: Lee, Seul-Yi, Vuong, Tuan Anh, Wen, Xianlan, Jeong, Hyeon-Ju, So, Hyun-Kyung, Kwon, Ilmin, Kang, Jong-Sun, Cho, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802672/
https://www.ncbi.nlm.nih.gov/pubmed/31601786
http://dx.doi.org/10.1038/s12276-019-0325-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802672/
https://www.ncbi.nlm.nih.gov/pubmed/31601786
http://dx.doi.org/10.1038/s12276-019-0325-0

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